Silver-Mediated Radical C(sp3)–H Biphosphinylation and Nitration of β-Alkynyl Ketones for Accessing Functional Isochromenes

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• 作者：Jun Sun ; Jiang-Kai Qiu ; Ya-Nan Wu ; Wen-Juan Hao ; Cheng Guo ; Guigen Li ; Shu-Jiang Tu ; Bo Jiang
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 17, 2017
• 年：2017
• 卷：19
• 期：4
• 页码：754-757
• 全文大小：434K
• ISSN：1523-7052

文摘

Silver-mediated C(sp³)–H functionalization and 6-endo-dig oxo-cyclization of conjugated β-alkynyl ketones have been established under oxidative conditions. The reaction leads to the concise formation of a wide range of isochromenes via C(sp³)–H bond-breaking and radical addition steps. Dual and monofunctional isochromene products were selectively controlled by using either electron-rich or electron-deficient radical sources.