Chiral Phosphoric Acid Catalyzed Intramolecular Dearomative Michael Addition of Indoles to Enones

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• 作者：Yong Zhou ; Zi-Lei Xia ; Qing Gu ; Shu-Li You
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 17, 2017
• 年：2017
• 卷：19
• 期：4
• 页码：762-765
• 全文大小：408K
• ISSN：1523-7052

文摘

An enantioselective intramolecular dearomative Michael addition of indolyl enones is presented. In the presence of catalytic amount of chiral phosphoric acid, various enantioenriched spiro-indolenines bearing a quaternary stereogenic center were obtained with good yields and enantioselectivity (up to 97% ee) under mild reaction conditions.