PhI(OCOCF3)2-Mediated Construction of a 2-Spiropseudoindoxyl Skeleton via Cascade Annulation of 2-Sulfonamido-N-phenylpropiolamide Derivatives

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• 作者：Bobo Zhang ; Xiang Zhang ; Bei Hu ; Desong Sun ; Senlin Wang ; Daisy Zhang-Negrerie ; Yunfei Du
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 17, 2017
• 年：2017
• 卷：19
• 期：4
• 页码：902-905
• 全文大小：394K
• ISSN：1523-7052

文摘

A cascade annulation of 2-sulfonamido-N-phenylpropiolamide derivatives leading to the construction of the 2-spiropseudoindoxyl skeleton was realized under mild conditions with phenyliodine(III) bis(trifluoroacetate) (PIFA) as the sole oxidant. This metal-free spirocyclization process is suggested to encompass a sequential C(sp²)–C(sp) and C(sp²)–N bond formation with the concomitant introduction of a carbonyl oxygen.