Ruthenium(0)-Catalyzed C–C Coupling of Alkynes and 3-Hydroxy-2-oxindoles: Direct C–H Vinylation of Alcohols

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• 作者：Tom Luong ; Shujie Chen ; Ke Qu ; Emma L. McInturff ; Michael J. Krische
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 17, 2017
• 年：2017
• 卷：19
• 期：4
• 页码：966-968
• 全文大小：369K
• ISSN：1523-7052

文摘

Upon exposure to a ruthenium(0) catalyst, N-benzyl-3-hydroxy-2-oxindoles react with diverse alkynes to form products of C–H vinylation with complete control of regioselectivity and olefin geometry. This method contributes to a growing body of catalytic processes that enable direct conversion of lower alcohols to higher alcohols in the absence of stoichiometric organometallic reagents.