Iodine-Catalyzed Direct C–H Alkenylation of Azaheterocycle N-Oxides with Alkenes

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• 作者：Zhenhao Zhang ; Chao Pi ; Heng Tong ; Xiuling CuiYangjie Wu
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 3, 2017
• 年：2017
• 卷：19
• 期：3
• 页码：440-443
• 全文大小：399K
• ISSN：1523-7052

文摘

An efficient and regioselective alkenylation of azaheterocycle N-oxides with alkenes catalyzed by iodine under metal- and external oxidant-free reaction conditions has been developed. A variety of (E)-2-styrylazaheterocycles have been produced in moderate to excellent yields. The mechanistic exploration indicated that the N-oxide group played dual roles as both the directing group and an internal oxidant in this catalytic cycle.