Cobalt(II)-Catalyzed Oxidative C–H Arylation of Indoles and Boronic Acids

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• 作者：Xinju Zhu ; Jian-Hang Su ; Cong Du ; Zheng-Long Wang ; Chang-Jiu Ren ; Jun-Long Niu ; Mao-Ping Song
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 3, 2017
• 年：2017
• 卷：19
• 期：3
• 页码：596-599
• 全文大小：383K
• ISSN：1523-7052

文摘

Co(II)-catalyzed C–H C2 selective arylation of indoles with boronic acids through monodentate chelation assistance has been achieved for the first time. The unique features of this methodology include mild reaction conditions, highly C2 regioselectivity, and employment of a Grignard reagent-free catalytic system. A wide range of substrates, including unreactive arenes, are well tolerated, which enables the construction of the coupling products efficiently. This new strategy provides an alternative and versatile approach to construct biaryls using inexpensive cobalt catalyst.