Diastereoselective Radical Oxidative C–H Aminations toward Chiral Atropoisomeric (P, N) Ligand Precursors

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• 作者：Yan-Na Ma ; Ming-Xing Cheng ; Shang-Dong Yang
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 3, 2017
• 年：2017
• 卷：19
• 期：3
• 页码：600-603
• 全文大小：490K
• ISSN：1523-7052

文摘

A new class of chiral atropoisomeric (P, N) ligand precursors has been obtained with excellent diastereoselectivities and high yields through diastereoselective metal-free intramolecular radical oxidative C–H amination with chiral phosphamide as the auxiliary group. This method provides a concise and highly valuable pathway for the synthesis of enantiopure aminophosphine ligands in large-scale.