Total Syntheses of (−)-Hibiscone C and Lysergine: A Cyclization/Fragmentation Strategy

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• 作者：Yandong Lu ; Haosen Yuan ; Shijie Zhou ; Tuoping Luo
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 3, 2017
• 年：2017
• 卷：19
• 期：3
• 页码：620-623
• 全文大小：375K
• ISSN：1523-7052

文摘

The first asymmetric total synthesis of (−)-hibiscone C and a concise synthesis of ergot alkaloid lysergine are described. Both syntheses were achieved using the radical cyclization/fragmentation strategy. This cascade reaction enabled the application of the strained bicycle as a synthon for the synthesis of highly substituted decalins in an efficient and stereoselective manner.