Palladium-Catalyzed Redox-Neutral N–O/C(sp3)–H Functionalization of Aryl Oximes with Isocyanides

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• 作者：Weigao Hu ; Jiawei Li ; Yanli Xu ; Jianxiao Li ; Wanqing Wu ; Haiyang Liu ; Huanfeng Jiang
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 3, 2017
• 年：2017
• 卷：19
• 期：3
• 页码：678-681
• 全文大小：421K
• ISSN：1523-7052

文摘

A redox-neutral palladium-catalyzed N–O/C(sp³)–H functionalization of aryl oximes with isocyanides has been developed. Various pyrrole derivatives were prepared in good to excellent yields through oxime carbamate as a key intermediate and internal oxidant in this process. Furthermore, this transformation also features readily available starting materials, good functional group tolerance, and excellent regioselectivity.