Catalytic Radical Trifluoromethylalkynylation of Unactivated Alkenes

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• 作者：Shaofang Zhou ; Tao Song ; He Chen ; Zhonglin Liu ; Haigen Shen ; Chaozhong Li
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 3, 2017
• 年：2017
• 卷：19
• 期：3
• 页码：698-701
• 全文大小：374K
• ISSN：1523-7052

文摘

The trifluoromethylalkynylation of unactivated alkenes with alkynyl sulfones and Togni’s reagent was developed. The reaction was catalyzed by 2,4,6-trimethylpyridine, leading to various β-trifluoromethylated alkynes under metal-free conditions with a broad substrate scope and wide functional group compatibility. A mechanism involving catalytic nonchain radical processes is proposed.