Ganotheaecolin A, a Neurotrophic Conjugated Ergosterol with a Naphtho[1,8-ef]azulene Scaffold from Ganoderma theaecolum

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• 作者：Qi Luo ; Zhu-Liang Yang ; Yong-Ming Yan ; Yong-Xian Cheng
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 3, 2017
• 年：2017
• 卷：19
• 期：3
• 页码：718-721
• 全文大小：300K
• ISSN：1523-7052

文摘

Ganotheaecolin A (1), a novel ergosterol with a rare naphtho[1,8-ef]azulene ring system, was isolated from the fruiting bodies of Ganoderma theaecolum. Its structure was determined by spectroscopic data and computational methods. Compound 1 represents a 6/6/7/5-fused carbon skeletal ergosterol typically formed by Wagner–Meerwein rearrangement, whose plausible biosynthetic pathway was briefly discussed. Finally, the neurotrophic activity of 1 was examined using PC12 cells.