Trichloroisocyanuric Acid Promoted Cascade Cyclization/Trifluoromethylation of Allylic Oximes: Synthesis of Trifluoromethylated Isoxazolines

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• 作者：Weigang Zhang ; Yingpeng SuKe-Hu Wang ; Lili Wu ; Bingbing Chang ; Ya Shi ; Danfeng Huang ; Yulai Hu
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：January 20, 2017
• 年：2017
• 卷：19
• 期：2
• 页码：376-379
• 全文大小：420K
• ISSN：1523-7052

文摘

Cheap and commercially available trichloroisocyanuric acid has been used to promote trifluoromethylation by using TMSCF₃ as the trifluoromethyl source. The method provides a novel and efficient protocol for the construction of CF₃-containing 4,5-dihydroisoxazoles from allylic oximes in good to excellent yields.