Four Matrine-Based Alkaloids with Antiviral Activities against HBV from the Seeds of Sophora alopecuroides

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• 作者：Yu-Bo Zhang ; Xiao-Li Zhang ; Neng-Hua Chen ; Zhong-Nan Wu ; Wen-Cai YeYao-Lan Li ; Guo-Cai Wang
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：January 20, 2017
• 年：2017
• 卷：19
• 期：2
• 页码：424-427
• 全文大小：348K
• ISSN：1523-7052

文摘

Four novel matrine-based alkaloids (1–4) were isolated from the seeds of Sophora alopecuroides. Compounds 1 and 2 possess unprecedented 6/6/6/4 and 6/5/6/6 ring systems, respectively, while 3 and 4 are a pair of stereoisomeric matrine–acetophenone alkaloids with an unusual skeleton. Their structures were elucidated by means of spectroscopic methods and single-crystal X-ray diffraction. Hypothetical biogenetic pathways for 1–4 are proposed, and their antiviral activities are also discussed.