Visible-Light-Induced Acetalization of Aldehydes with Alcohols

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• 作者：Hong Yi ; Linbin Niu ; Shengchun Wang ; Tianyi Liu ; Atul K. Singh ; Aiwen Lei
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：January 6, 2017
• 年：2017
• 卷：19
• 期：1
• 页码：122-125
• 全文大小：380K
• ISSN：1523-7052

文摘

In this work, we have achieved a simple and general method for acetalization of aldehydes by means of a photochemical reaction under low-energy visible light irradiation. A broad range of aromatic, heteroaromatic, and aliphatic aldehydes have been protected under neutral conditions in good to excellent yields using a catalytic amount of Eosin Y as the photocatalyst. Our visible light mediated acetalization strategies are successful for more challenging acid-sensitive aldehydes and sterically hindered aldehydes. Notably, this protocol is chemoselective to aldehydes, while ketones remain intact.