Tandem Addition/Cyclization for Access to Isoquinolines and Isoquinolones via Catalytic Carbopalladation of Nitriles

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• 作者：Linjun Qi ; Kun Hu ; Shuling Yu ; Jianghe Zhu ; Tianxing Cheng ; Xiaodong Wang ; Jiuxi ChenHuayue Wu
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：January 6, 2017
• 年：2017
• 卷：19
• 期：1
• 页码：218-221
• 全文大小：416K
• ISSN：1523-7052

文摘

The first example of the palladium-catalyzed sequential nucleophilic addition followed by an intramolecular cyclization of functionalized nitriles with arylboronic acids has been achieved, providing an efficient synthetic pathway to access structurally diverse isoquinolines and isoquinolones. This methodology has also been successfully applied to the total synthesis of the topoisomerase I inhibitor CWJ-a-5 (free base).