Commiphoranes A–D, Carbon Skeletal Terpenoids from Resina Commiphora

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• 作者：Lu Dong ; Li-Zhi Cheng ; Yong-Ming Yan ; Shu-Mei Wang ; Yong-Xian Cheng
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：January 6, 2017
• 年：2017
• 卷：19
• 期：1
• 页码：286-289
• 全文大小：321K
• ISSN：1523-7052

文摘

Commiphoranes A–D (1–4), four novel aromatic terpenoids with unprecedented carbon skeletons, were isolated from Resina Commiphora. Their structures were identified by spectroscopic and crystallographic methods. Compounds 1 and 2 are dinorditerpenoids characteristic of a 6/6/6/6 ring system. In contrast, compounds 3 and 4 are sesquiterpenoids possessing a 5/6/7 backbone. Biological evaluation reveals that 3 could significantly attenuate overproduction of fibronectin, collagen I, and α-SMA in TGF-β1-induced rat renal proximal tubular cells.