Folate-Engineered Microvesicles for Enhanced Target and Synergistic Therapy toward Breast Cancer

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• 作者：Lian Zhu ; Di Dong ; Zi-Li Yu ; Yi-Fang Zhao ; Dai-Wen Pang ; Zhi-Ling Zhang
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2017
• 出版时间：February 15, 2017
• 年：2017
• 卷：9
• 期：6
• 页码：5100-5108
• 全文大小：503K
• ISSN：1944-8252

文摘

As an ideal nanovector candidate, microvesicles (MVs) have been gradually utilized for packaging kinds of functional molecules for effective tumor diagnosis and therapy; however, the deficiency of their tumor targeting influenced their therapy efficacy. Through a facile phospholipid substitution strategy, MVs-based drug delivery system (DDS) was apparently endowed with high tumor targeting toward breast cancer thanks to the modified folate onto the membrane of MVs, simultaneously possessing a synergistic antitumor effect, and in vivo tumor imaging attributed to the SA-QDs labeling. Tumor killing effect could be improved up to 15 percentages with the help of the improved tumor targeting ability.