Fabrication of Antibacterial and Antiwear Hydroxyapatite Coatings via In Situ Chitosan-Mediated Pulse Electrochemical Deposition

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• 作者：Ling Yan ; Yi Xiang ; Jia Yu ; Yingbo Wang ; Wenguo Cui
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2017
• 出版时间：February 8, 2017
• 年：2017
• 卷：9
• 期：5
• 页码：5023-5030
• 全文大小：519K
• ISSN：1944-8252

文摘

Although bioinert titanium has been widely applied in orthopedics and related fields, its usage is limited by its unsatisfying osteoinductivity, anti-infection capability, and wear-resistance. Osteoinductive apatite coating can be fabricated on a titanium surface by electrochemical methods, but this causes bacterial adhesion and poor wear-resistance. On the basis of pulse electrochemical technology, a wear-resistance and antibacterial osteoinductive coating was fabricated through codeposition of hydroxyapatite (HA) and nano-Ag effectuated by the cohybridization ofchitosan (CS) with Ag⁺ and Ca²⁺. A composite coating formed with uniformly dispersed spherical nanoparticles was obtained at optimized deposition potential, Ag concentration, and apatite concentration. The nanocomposite coating shows excellent bioinductive activity; it promotes preferential growth on the (002) face, and needle-like ordered arrangement of apatite. Due to the mediation of CS hybridization, a compact structure is achieved in the HA/Ag composite coating which significantly enhances the wear-resistance of the coating and reduces the release of Ca²⁺ and Ag⁺. The antibacterial rate of the coating on Escherichia coli and Staphylococcus aureus is up to 99% according to the antibacterial test. In conclusion, a wear-resistant and long-term antibacterial bioactive nanocomposite coating is successfully fabricated on titanium surface through the strategy established in this study.