A Programmable DNA Double-Write Material: Synergy of Photolithography and Self-Assembly Nanofabrication

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• 作者：Youngjun Song ; Tsukasa Takahashi ; Sejung Kim ; Yvonne C. Heaney ; John Warner ; Shaochen Chen ; Michael J. Heller
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2017
• 出版时间：January 11, 2017
• 年：2017
• 卷：9
• 期：1
• 页码：22-28
• 全文大小：533K
• ISSN：1944-8252

文摘

We demonstrate a DNA double-write process that uses UV to pattern a uniquely designed DNA write material, which produces two distinct binding identities for hybridizing two different complementary DNA sequences. The process requires no modification to the DNA by chemical reagents and allows programmed DNA self-assembly and further UV patterning in the UV exposed and nonexposed areas. Multilayered DNA patterning with hybridization of fluorescently labeled complementary DNA sequences, biotin probe/fluorescent streptavidin complexes, and DNA patterns with 500 nm line widths were all demonstrated.