Gradient and Patterned Protein Films Stabilized via Nanoimprint Lithography for Engineered Interactions with Cells

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• 作者：Li-Sheng Wang ; Bradley Duncan ; Rui TangYi-Wei Lee ; Brian Creran ; Sukru Gokhan Elci ; Jiaxin Zhu ; Gülen Yesilbag Tonga ; Jesse Doble ; Matthew Fessenden ; Mahin Bayat ; Stephen Nonnenmann ; Richard W. Vachet ; Vincent M. Rotello
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2017
• 出版时间：January 11, 2017
• 年：2017
• 卷：9
• 期：1
• 页码：42-46
• 全文大小：433K
• ISSN：1944-8252

文摘

Protein-based biomaterials provide versatile scaffolds for generating functional surfaces for biomedical applications. However, tailoring the functional and biological properties of protein films remains a challenge. Here, we describe a high-throughput method to designing stable, functional biomaterials by combining inkjet deposition of protein inks with a nanoimprint lithography based methodology. The translation of the intrinsically charged proteins into functional materials properties was demonstrated through controlled cellular adhesion. This modular strategy offers a rapid method to produce customizable biomaterials.