Antifouling Manganese Oxide Nanoparticles: Synthesis, Characterization, and Applications for Enhanced MR Imaging of Tumors

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• 作者：Peng Wang ; Jia Yang ; Benqing Zhou ; Yong Hu ; Lingxi Xing ; Fanli Xu ; Mingwu Shen ; Guixiang Zhang ; Xiangyang Shi
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2017
• 出版时间：January 11, 2017
• 年：2017
• 卷：9
• 期：1
• 页码：47-53
• 全文大小：489K
• ISSN：1944-8252

文摘

Antifouling manganese oxide (Mn₃O₄) nanoparticles (NPs) were synthesized by solvothermal decomposition of tris(2,4-pentanedionato) manganese(III) in the presence of trisodium citrate, followed by surface modification with polyethylene glycol and l-cysteine. The as-prepared nanoparticles have a uniform size distribution, good colloidal stability and good cytocompatibility. The modification of l-cysteine rendered the particles with much longer blood circulation time (half-decay time of 28.4 h) than those without l-cysteine modification (18.5 h), and decreased macrophage cellular uptake. Thanks to desirable antifouling property and relatively high r₁ relaxivity (3.66 mM^–1 s^–1), the l-cysteine-modified Mn₃O₄ NPs can be used for enhanced tumor magnetic resonance imaging applications.