Graphene Oxide Directed One-Step Synthesis of Flowerlike Graphene@HKUST-1 for Enzyme-Free Detection of Hydrogen Peroxide in Biological Samples

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• 作者：Qingxiang Wang ; Yizhen Yang ; Feng Gao ; Jiancong Ni ; Yanhui Zhang ; Zhenyu Lin
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：November 30, 2016
• 年：2016
• 卷：8
• 期：47
• 页码：32477-32487
• 全文大小：659K
• ISSN：1944-8252

文摘

A novel metal–organic framework (MOF)-based electroactive nanocomposite containing graphene fragments and HKUST-1 was synthesized via a facile one-step solvothermal method using graphene oxide (GO), benzene-1,3,5-tricarboxylic acid (BTC), and copper nitrate (Cu(NO₃)₂) as the raw materials. The morphology and structure characterization revealed that the GO could induce the transformation of HKUST-1 from octahedral structure to the hierarchical flower shape as an effective structure-directing agent. Also, it is interesting to find out that the GO was torn into small fragments to participate in the formation of HKUST-1 and then transformed into the reduction form during the solvothermal reaction process, which dramatically increased the surface area, electronic conductivity, and redox-activity of the material. Electrochemical assays showed that the synergy of graphene and HKUST-1 in the nanocomposite leaded to high electrocatalysis, fast response, and excellent selectivity toward the reduction of hydrogen peroxide (H₂O₂). Based on these remarkable advantages, satisfactory results were obtained when the nanocomposite was used as a sensing material for electrochemical determination of H₂O₂ in the complex biological samples such as human serum and living Raw 264.7 cell fluids.