“Cut and Sew” Transformations via Transition-Metal-Catalyzed Carbon–Carbon Bond Activation

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• 作者：Peng-hao Chen ; Brent A. Billett ; Tatsuhiro Tsukamoto ; Guangbin Dong
• 刊名：ACS Catalysis
• 出版年：2017
• 出版时间：February 3, 2017
• 年：2017
• 卷：7
• 期：2
• 页码：1340-1360
• 全文大小：2115K
• ISSN：2155-5435

文摘

The transition-metal-catalyzed “cut and sew” transformation has recently emerged as a useful strategy for preparing complex molecular structures. After oxidative addition of a transition metal into a carbon–carbon bond, the resulting two carbon termini can be both functionalized in one step via a following migratory insertion and reductive elimination with unsaturated units, such as alkenes, alkynes, allenes, CO, and polar multiple bonds. Three- or four-membered rings are often employed as reaction partners due to their high ring strains. The participation of nonstrained structures generally relies on cleavage of a polar carbon–CN bond or assistance of a directing group.