Acid-Assisted Ru-Catalyzed Enantioselective Amination of 1,2-Diols through Borrowing Hydrogen

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• 作者：Li-Cheng Yang ; Ya-Nong Wang ; Yao Zhang ; Yu Zhao
• 刊名：ACS Catalysis
• 出版年：2017
• 出版时间：January 6, 2017
• 年：2017
• 卷：7
• 期：1
• 页码：93-97
• 全文大小：411K
• ISSN：2155-5435

文摘

Here, we present a highly enantioselective synthesis of 1,2-amino alcohols from readily available racemic 1,2-diols through a borrowing hydrogen process. An intriguing acid effect was discovered for this Ru-catalyzed amination reaction, which led to a significant improvement of the stereoselectivity of the process. Preliminary mechanistic studies suggest a scenario of Brønsted acid-assisted dynamic kinetic asymmetric amination of alcohols.