Asymmetric Hydrogenation of Allylic Alcohols Using Ir–N,P-Complexes

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• 作者：Jia-Qi Li ; Jianguo Liu ; Suppachai Krajangsri ; Napasawan Chumnanvej ; Thishana Singh ; Pher G. Andersson
• 刊名：ACS Catalysis
• 出版年：2016
• 出版时间：December 2, 2016
• 年：2016
• 卷：6
• 期：12
• 页码：8342-8349
• 全文大小：612K
• ISSN：2155-5435

文摘

In this study, a series of γ,γ-disubstituted and β,γ-disubstituted allylic alcohols were prepared and successfully hydrogenated using suitable N,P-based Ir complexes. High yields and excellent enantioselectivities were obtained for most of the substrates studied. This investigation also revealed the effect of the acidity of the N,P–Ir-complexes on the acid-sensitive allylic alcohols. DFT ΔpK_a calculations were used to explain the effect of the N,P-ligand on the acidity of the corresponding Ir-complex. The selectivity model of the reaction was used to accurately predict the absolute configuration of the hydrogenated alcohols.