Ultrasmall Biocompatible Bi2Se3 Nanodots for Multimodal Imaging-Guided Synergistic Radiophotothermal Therapy against Cancer

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• 作者：Fangxin Mao ; Ling Wen ; Caixia Sun ; Shaohua Zhang ; Guanglin Wang ; Jianfeng Zeng ; Yong Wang ; Jianmin Ma ; Mingyuan Gao ; Zhen Li
• 刊名：ACS Nano
• 出版年：2016
• 出版时间：December 27, 2016
• 年：2016
• 卷：10
• 期：12
• 页码：11145-11155
• 全文大小：707K
• ISSN：1936-086X

文摘

Sub-3 nm ultrasmall Bi₂Se₃ nanodots stabilized with bovine serum albumin were successfully synthesized through a reaction of hydroxyethylthioselenide with bismuth chloride in aqueous solution under ambient conditions. These nanodots exhibit a high photothermal conversion efficiency (η = 50.7%) due to their strong broad absorbance in the near-infrared (NIR) window and serve as a nanotheranostic agent for photoacoustic imaging and photothermal cancer therapy. In addition, they also display radioenhancement with a ratio of 6% due to their sensitivity to X-rays, which makes them a potential sensitizer for radiotherapy. These nanodots were also labled with radioactive ^99mTc for quantification of their biodistribution by single-photon-emission computed tomography (SPECT)/computed tomography (CT) imaging. Our work demonstrates the potential of ultrasmall Bi₂Se₃ nanodots in multimodal imaging-guided synergetic radiophotothermal therapy of cancer.