Efficient DNA-Mediated Electron Transport in Ionic Liquids

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• 作者：Shuguang Xuan ; Zhenyu Meng ; Xiangyang Wu ; Jiun-Ru Wong ; Gitali Devi ; Edwin Kok Lee Yeow ; Fangwei Shao
• 刊名：ACS Sustainable Chemistry & Engineering
• 出版年：2016
• 出版时间：December 5, 2016
• 年：2016
• 卷：4
• 期：12
• 页码：6703-6711
• 全文大小：435K
• ISSN：2168-0485

文摘

Electron conductivity of duplex DNA has promising applications in fabricating DNA based biosensors and electronic devices for biomimic solar cells. However, in aqueous solution DNA-mediated electron transfer (ET) is often far from ideal for these applications. We reported here that in hydrated ionic liquids (IL) electron can propagate through 4 nm of duplex DNA, and higher ET efficiency was achieved over longer distance which yielded a noncanonical negative distance decay parameter (γ = −0.02 Å^–1). Fluorescence studies and ET efficiency of duplex DNA in IL-D₂O revealed that the binding of both cationic and anionic species of hydrated IL in DNA minor groove and the exclusion of water from the DNA hydration layer significantly improved base-pair stacking of duplex DNA to achieve efficient electric conductivity. As an oxidation reaction of nucleic acids, efficient DNA ET observed here suggested that IL could be a promising nonorganic and nonaqueous solvent for redox reactions of biomacromolecules.