High-Pressure Compression-Molded Porous Resorbable Polymer/Hydroxyapatite Composite Scaffold for Cranial Bone Regeneration

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• 作者：Jin Zhang ; He Liu ; Jian-Xun Ding ; Jie Wu ; Xiu-Li Zhuang ; Xue-Si Chen ; Jin-Cheng Wang ; Jing-Bo Yin ; Zhong-Ming Li
• 刊名：ACS Biomaterials Science & Engineering
• 出版年：2016
• 出版时间：September 12, 2016
• 年：2016
• 卷：2
• 期：9
• 页码：1471-1482
• 全文大小：954K
• ISSN：2373-9878

文摘

Fabricating porous scaffolds with sufficient mechanical properties is a challenge for healing bone defects. High-pressure compression-molded (HPCM) porous composite scaffold comprising poly(l-lactide) (PLLA), poly(lactide-co-glycolide) (PLGA), and hydroxyapatite (HA) was prepared and showed upregulated mechanical properties due to a solid network structure and a highly ordered crystalline architecture. The compressive yield strength and modulus of the HPCM scaffold molded at 1000 MPa and 180 °C were 0.91 and 6.84 MPa, respectively. The HPCM scaffold also exhibited an interconnected porous architecture with porosity greater than 80%, an appropriate degradation rate, and enhanced cell proliferation. Moreover, the HPCM scaffold supported the healing of a rat calvarial defect in vivo.