Aggregation State Reactivity Activation of Intramolecular Charge Transfer Type Fluorescent Probe and Application in Trace Vapor Detection of Sarin Mimics

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• 作者：Wei Xu ; Yanyan Fu ; Junjun Yao ; Tianchi Fan ; Yixun Gao ; Qingguo He ; Defeng Zhu ; Huimin Cao ; Jiangong Cheng
• 刊名：ACS Sensor
• 出版年：2016
• 出版时间：August 26, 2016
• 年：2016
• 卷：1
• 期：8
• 页码：1054-1059
• 全文大小：559K
• ISSN：2379-3694

文摘

The reactivity of most Intramolecular Charge Transfer (ICT) based probes in the film state is much poorer than that in solution, due to the serious solid state aggregation of the large polarity molecules. In this contribution, an efficient method for activating the aggregation state reactivity of ICT based probes has been developed. Multiple hydrogen bonds formed by the oxime group, together with the phenol anion, could activate the aggregation state reactivity of the oxime group. By enhancing frontier orbital energy level, and constructing porous film structure, the probe becomes more compatible for highly efficient vapor phase reaction. In application, the TOP-I film can distinguish different organic phosphates with significant fluorescence change. The detection limit for diethyl chloro phosphate (DCP) is 1.2 ppb, lower than the Immediately Dangerous to Life and Health (IDLH) level of Sarin. Such a reactivity activating strategy can be extended to detect other harmful vapors by inducing suitable functional groups as the acceptor of the ICT system. Furthermore, with the increasing importance of green chemistry, the method may be beneficial for applications in solvent-free reactions.