Novel Tumor-Specific and Mitochondria-Targeted near-Infrared-Emission Fluorescent Probe for SO2 Derivatives in Living Cells

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• 作者：Jin Yang ; Kun Li ; Ji-Ting Hou ; Ling-Ling Li ; Chun-Yan Lu ; Yong-Mei Xie ; Xin Wang ; Xiao-Qi Yu
• 刊名：ACS Sensor
• 出版年：2016
• 出版时间：February 26, 2016
• 年：2016
• 卷：1
• 期：2
• 页码：166-172
• 全文大小：590K
• ISSN：2379-3694

文摘

Endogenous sulfur dioxide (SO₂) is an important gaseous signal molecule, which was also regarded as one of the reactive sulfur spaces (RSS) and closely related to cardiovascular diseases and many neurological disorders. However, the design and synthesis of fluorescent probes with near-infrared-emission which can detect mitochondrial SO₂ and its derivatives in living cells still remain unresolved. Herein, a biotin and coumarin-benzoindole conjugate BCS-1 was presented as a ratiometric and colorimetric fluorescent probe for tracing SO₂ derivatives with excellent selectivity and rapid responsibility. Notably, it is the first mitochondria-targeted near-infrared-emission probe that could selectively detect SO₂ in tumor cells. BCS-1 could selectively enter into mitochondria of tumor cells, and the detection limit for SO₂ derivatives was determined as 72 nM.