Enhanced Stability of Core-Surface Cross-Linked Micelles Fabricated from Amphiphilic Brush Copolymers

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• 作者：Peisheng Xu ; Huadong Tang ; Shiyan Li ; Jun Ren ; Edward Van Kirk ; William J. Murdoch ; Maciej Radosz ; and Youqing Shen
• 刊名：Biomacromolecules
• 出版年：2004
• 出版时间：September 2004
• 年：2004
• 卷：5
• 期：5
• 页码：1736 - 1744
• 全文大小：169K
• 年卷期：v.5,no.5(September 2004)
• ISSN：1526-4602

文摘

"Stealth" nanoparticles made from polymer micelles have been widely explored as drug carriers for targeteddrug delivery. High stability (i.e., low critical micelle concentration (CMC)) is required for their intravenousapplications. Herein, we present a "core-surface cross-linking" concept to greatly enhance nanoparticle'sstability: amphiphilic brush copolymers form core-surface cross-linked micelles (nanoparticles) (SCNs).The amphiphilic brush copolymers consisted of hydrophobic poly(-caprolactone) (PCL) and hydrophilicpoly(ethylene glycol) (PEG) or poly(2-(N,N-dimethylamino)ethyl methacrylate) (PDMA) chains weresynthesized by macromonomer copolymerization method and used to demonstrate this concept. The resultingSCNs were about 100 times more stable than micelles from corresponding amphiphilic block copolymers.The size and surface properties of the SCNs could be easily tailored by the copolymer's compositions.