Synthesis and Characterization of Biocompatible Thermo-Responsive Gelators Based on ABA Triblock Copolymers

详细信息    查看全文

• 作者：Chengming Li ; Yiqing Tang ; Steven P. Armes ; Christopher J. Morris ; Susanna F. Rose ; Andrew W. Lloyd ; and Andrew L. Lewis
• 刊名：Biomacromolecules
• 出版年：2005
• 出版时间：March 2005
• 年：2005
• 卷：6
• 期：2
• 页码：994 - 999
• 全文大小：181K
• 年卷期：v.6,no.2(March 2005)
• ISSN：1526-4602

文摘

The synthesis of biocompatible, thermo-responsive ABA triblock copolymers in which the outer A blockscomprise poly(N-isopropylacrylamide) and the central B block is poly(2-methacryloyloxyethyl phosphorylcholine) is achieved using atom transfer radical polymerization with a commercially available bifunctionalinitiator. These novel triblock copolymers are water-soluble in dilute aqueous solution at 20 C and pH 7.4but form free-standing physical gels at 37 C due to hydrophobic interactions between the poly(N-isopropylacrylamide) blocks. This gelation is reversible, and the gels are believed to contain nanosizedmicellar domains; this suggests possible applications in drug delivery and tissue engineering.