Automated nanospray using chip-based emitters for the quantitative analysis of pharmaceutical compounds

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• 作者：Leonard J. Corkery (1) (2)
  Henrianna Pang (1)
  Bradley B. Schneider (3)
  Thomas R. Covey (3)
  K. W. Michael Siu (2)
  
• 刊名：Journal of The American Society for Mass Spectrometry
• 出版年：2005
• 出版时间：March 2005
• 年：2005
• 卷：16
• 期：3
• 页码：363-369
• 全文大小：121KB
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• 作者单位：Leonard J. Corkery (1) (2)
  Henrianna Pang (1)
  Bradley B. Schneider (3)
  Thomas R. Covey (3)
  K. W. Michael Siu (2)
  
  1. Eli Lilly Canada Inc., Toronto, Ontario, Canada
  2. Department of Chemistry and Center for Research in Mass Spectrometry, York University, Toronto, Ontario, Canada
  3. MDS SCIEX, Concord, Ontario, Canada
  

文摘

An automated nanospray system based on chip technology (the NanoMate) was successfully interfaced to a modified Particle Discriminator Interface on a triple quadrupole mass spectrometer. A number of the interface parameters were optimized to improve the sampling efficiency for ions from the chip-based system. Analytical performance was assessed using a number of biochemicals as well as via a methodology for a pharmaceutical that passed validation as required by Good Laboratory Practices. Infusion analyses in flow rates <1 μL/min provided advantages in terms of throughput and sample consumption when compared to other methodologies based on liquid chromatography.