5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice

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• 作者：Yongsheng Wang (1)
  Changyang Gong (1)
  Li Yang (1)
  Qinjie Wu (1)
  Shuai Shi (1)
  Huashan Shi (1)
  Zhiyong Qian (1)
  Yuquan Wei (1)
  
• 刊名：BMC Cancer
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：10
• 期：1
• 全文大小：6652KB
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  29. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/10/402/prepub
  
• 作者单位：Yongsheng Wang (1)
  Changyang Gong (1)
  Li Yang (1)
  Qinjie Wu (1)
  Shuai Shi (1)
  Huashan Shi (1)
  Zhiyong Qian (1)
  Yuquan Wei (1)
  
  1. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, China
  
• ISSN：1471-2407

文摘

Background Colorectal peritoneal carcinomatosis (CRPC) is a common form of systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that a new system, 5-FU-loaded hydrogel system, can improve the therapeutic effects of intraperitoneal chemotherapy. Methods A biodegradable PEG-PCL-PEG (PECE) triblock copolymer was successfully synthesized. The biodegradable and temperature sensitive hydrogel was developed to load 5-FU. Methylene blue-loaded hydrogel were also developed for visible observation of the drug release. The effects and toxicity of the 5-FU-hydrogel system were evaluated in a murine CRPC model. Results The hydrogel system is an injectable flowing solution at ambient temperature and forms a non-flowing gel depot at physiological temperature. 5-FU-hydrogel was subsequently injected into abdominal cavity in mice with CT26 cancer cells peritoneal dissemination. The results showed that the hydrogel delivery system prolonged the release of methylene blue; the 5-FU-hydrogel significantly inhibited the peritoneal dissemination and growth of CT26 cells. Furthermore, intraperitoneal administration of the 5-FU-hydrogel was well tolerated and showed less hematologic toxicity. Conclusions Our data indicate that the 5-FU-hydrogel system can be considered as a new strategy for peritoneal carcinomatosis, and the hydrogel may provide a potential delivery system to load different chemotherapeutic drugs for peritoneal carcinomatosis of cancers.