Biocompatibility of Mg-Nd-Zn-Zr alloy with rabbit blood

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• 作者：YongPing Wang (1) (2)
  YuanMing Ouyang (2)
  YaoHua He (2)
  DaoYun Chen (2)
  Yao Jiang (2)
  Lin Mao (3)
  JiaLin Niu (3)
  Jian Zhang (3)
  GuangYin Yuan (3)
  
• 关键词：magnesium alloy ; hemocompatibility ; blood cell aggregation ; platelet adhesion ; protein adsorption
• 刊名：Chinese Science Bulletin
• 出版年：2013
• 出版时间：August 2013
• 年：2013
• 卷：58
• 期：23
• 页码：2903-2908
• 全文大小：681KB
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• 作者单位：YongPing Wang (1) (2)
  YuanMing Ouyang (2)
  YaoHua He (2)
  DaoYun Chen (2)
  Yao Jiang (2)
  Lin Mao (3)
  JiaLin Niu (3)
  Jian Zhang (3)
  GuangYin Yuan (3)
  
  1. Department of Orthopaedics, First Hospital of Lanzhou University, Lanzhou, 730000, China
  2. Department of Orthopaedics, Sixth People鈥檚 Hospital of Shanghai Jiao Tong University, Shanghai, 200233, China
  3. National Engineering Research Center of Light Alloys Net Forming, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China
  
• ISSN：1861-9541

文摘

In this study, in vitro blood biocompatibility of Mg-Nd-Zn-Zr (JDBM) alloy was investigated to determine its suitability as a degradable medical biomaterial. Blood biocompatibility was assessed by blood cell aggregation, platelet adhesion, and protein adsorption. A titanium alloy was used as control. The results showed that the JDBM alloy did not induce significant blood cell aggregation, platelet adhesion, and protein adsorption comparison with the titanium alloy (P>0.05). Our data indicate that the JDBM alloy has excellent in vitro blood compatibility, and thus can be considered as a potential degradable biomaterial for medical applications with respect to hemocompatibility.