Using mouse models to study function of transcriptional factors in T cell development

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• 作者：Peng Li (1) (2)
  Yiren Xiao (1) (2)
  Zhixin Liu (1) (2)
  Pentao Liu (3)
  
• 关键词：Genetic modified mice ; Humanized mice ; Lymphopoiesis ; T cell development ; Bcl11b
• 刊名：Cell Regeneration
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：1
• 期：1
• 全文大小：412KB
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• 作者单位：Peng Li (1) (2)
  Yiren Xiao (1) (2)
  Zhixin Liu (1) (2)
  Pentao Liu (3)
  
  1. Key Laboratory of Regenerative Biology, Guangzchou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
  2. Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, China
  3. Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK
  

文摘

Laboratory mice have widely been used as tools for basic biological research and models for studying human diseases. With the advances of genetic engineering and conditional knockout (CKO) mice, we now understand hematopoiesis is a dynamic stepwise process starting from hematopoietic stem cells (HSCs) which are responsible for replenishing all blood cells. Transcriptional factors play important role in hematopoiesis. In this review we compile several studies on using genetic modified mice and humanized mice to study function of transcriptional factors in lymphopoiesis, including T lymphocyte and Natural killer (NK) cell development. Finally, we focused on the key transcriptional factor Bcl11b and its function in regulating T cell specification and commitment.