Protection of Selenium on Hepatic Mitochondrial Respiratory Control Ratio and Respiratory Chain Complex Activities in Ducklings Intoxicated with Aflatoxin B1

详细信息    查看全文

• 作者：Dayou Shi (1)
  Shining Guo (1)
  Shenquan Liao (2)
  Rongsheng Su (1)
  Mingsheng Guo (1)
  Nian Liu (1)
  Pengfei Li (1)
  Zhaoxin Tang (1)
  
• 关键词：Sodium selenite ; Hepatic mitochondrial ; Respiratory chain complexes ; Respiratory control ratio ; Aflatoxin B1
• 刊名：Biological Trace Element Research
• 出版年：2012
• 出版时间：March 2012
• 年：2012
• 卷：145
• 期：3
• 页码：312-317
• 全文大小：125KB
• 参考文献：1. Wilson DM, Payne GA (1994) Factors affecting / Aspergillus flavus group infection and aflatoxin contamination of crops. In: Eaton DL, Groopman JD (eds) The toxicology of aflatoxins, 1st edn. Academic, San Diego, pp 123-45
  2. Adav SS, Godinwar SP (1997) Effects of aflatoxin B1 on liver microsomal enzymes in different strains of chickens. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 118:185-89 CrossRef
  3. Hamilton PB (1978) Fallacies in our understanding of mycotoxins. J Food Prot 41:404-08
  4. Essigmann JM, Croy RG, Bennett RA, Wogan GN (1982) Metabolic activation of aflatoxin B₁: patterns of DNA adduct formation, removal and excretion in relation to carcinogenesis. Drug Metab Rev 13:581-02 CrossRef
  5. Pederson PL (1978) Tumor mitochondria and bioenergetics of cancer cells. Prog Exp Tumor Res 22:190-74
  6. Garner RC (1980) Carcinogenesis by fungal products. Br Med Bull 36:47-2
  7. Sajan MP, Satav JG, Bhattacharya RK (1995) Activity of some respiratory enzymes and cytochrome contents in rat hepatic mitochondria following aflatoxin B₁ administration. Toxicol Lett 80:55-0 CrossRef
  8. Williams GM, Tanaka T, Maeura Y (1986) Dose-related inhibition of aflatoxin B1 induced hepatocarcinogenesis by the phenolic antioxidants, butylated hydroxyanisole and butylated hydroxytoluene. Carcinogenesis 7:1043-050 CrossRef
  9. Nyandieka HS, Wakhis J, Kilonzo MM (1990) Association of reduction of AFB₁-induced liver tumours by antioxidants with increased activity of microsomal enzymes. Indian J Med Res 92:332-36
  10. Shen HM, Shi CY, Lee HP, Ong CN (1994) Aflatoxin B1-induced lipid peroxidation in rat liver. Toxicol Appl Pharmacol 127:145-50 CrossRef
  11. Tang Z, Iqbal M, Cawthon D, Bottje WG (2002) Heart and breast muscle mitochondrial dysfunction in pulmonary hypertension syndrome in broilers ( / Gallus domesticus). Comp Biochem Physiol A Mol Integr Physiol 132:527-40 CrossRef
  12. Bradford HF, Dodd PR (1977) Convulsions and activation of epileptic foci induced by monosodium glutamate and related compounds. Biochem Pharmacol 26:253-54 CrossRef
  13. Zhang S, Fu J, Zhou Z (2004) In vitro effect of manganese chloride exposure on reactive oxygen species generation and respiratory chain complexes activities of mitochondria isolated from rat brain. Toxicol In Vitro 18:71-7 CrossRef
  14. Wogan GN (1999) Aflatoxin as a human carcinogen. Hepatology 30:573-75 CrossRef
  15. Sharma RA, Farmer PB (2004) Biological relevance of adduct detection to the chemoprevention of cancer. Clin Cancer Res 10:4901-912 CrossRef
  16. Klein PJ, Van Vleet TR, Hall JO, Coulombe RA Jr (2002) Biochemical factors underlying the age-related sensitivity of turkeys to aflatoxin B(1). Comp Biochem Physiol C Toxicol Pharmacol 132:193-01 CrossRef
  17. Preston RJ, Williams GM (2005) DNA-reactive carcinogens: mode of action and human cancer hazard. Crit Rev Toxicol 35:673-83 CrossRef
  18. Seyfried TN, Shelton LM (2010) Cancer as a metabolic disease. Nutr Metab (Lond) 7:7-8 CrossRef
  19. Ebringer L (1990) Interaction of drugs with extranuclear genetic elements and its consequences. Teratog Carcinog Mutagen 10:477-01 CrossRef
  20. Pedersen PL, Greenawalt JW, Reynafarje B, Hullihen J, Decker GL, Soper JW, Bustamente E (1978) Preparation and characterization of mitochondria and submitochondrial particles of rat liver and liver-derived tissues. Methods Cell Biol 20:411-81 CrossRef
  21. Sajan MP, Satav JG, Bhattacharya RK (1997) Effect of aflatoxin B in vitro on rat liver mitochondrial respiratory functions. Indian J Exp Biol 35:1187-190
  22. Sajan MP, Satav JG, Bhattacharya RK (1996) Alteration of energy-linked functions in rat hepatic mitochondria following aflatoxin B₁ administration. J Biochem Toxicol 11:235-41 CrossRef
  23. Towner RA, Qian SY, Kadiiska MB, Mason RP (2003) In vivo identification of aflatoxin-induced free radicals in rat bile. Free Radic Biol Med 35:1330-340 CrossRef
  24. Sohn DH, Kim YC, Oh SH, Park EJ, Li X, Lee BH (2003) Hepatoprotective and free radical scavenging effects of / Nelumbo nucifera. Phytomedicine 10:165-69 CrossRef
  25. Berg D, Youdim MB, Riederer P (2004) Redox imbalance. Cell Tissue Res 318:201-13 CrossRef
  26. Janssen YM, Van Houten B, Borm PJ, Mossman BT (1993) Cell and tissue responses to oxidative damage. Lab Invest 69:261-74
  
• 作者单位：Dayou Shi (1)
  Shining Guo (1)
  Shenquan Liao (2)
  Rongsheng Su (1)
  Mingsheng Guo (1)
  Nian Liu (1)
  Pengfei Li (1)
  Zhaoxin Tang (1)
  
  1. College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China
  2. Institute of Veterinary Medicine, Guangdong Academy of Agricultural Sciences, Guangzhou, 510640, China
  

文摘

To investigate the protection of selenium on hepatic mitochondrial functions, 90 7-day-old ducklings were randomly divided into three groups (groups I–III). Group I was used as a blank control. Group II was administered with aflatoxin B1 (0.1?mg/kg body weight). Group III was administered with aflatoxin B1 (0.1?mg/kg body weight) plus selenium (sodium selenite, 1?mg/kg body weight). All treatments were given once daily for 21?days. The results showed that the activities of hepatic mitochondrial complexes I–IV in group II ducklings significantly decreased when compared with group I (P-lt;-.01). Furthermore, the activities of hepatic mitochondrial complexes I–IV in group III significantly increased when compared with group II (P-lt;-.05). The hepatic mitochondrial respiratory control ratio (RCR) in group II ducklings significantly decreased when compared with group I (P-lt;-.01). In addition, the hepatic mitochondrial RCR in group III significantly increased when compared with group II (P-lt;-.05). These results revealed that the aflatoxin B1 significantly induced hepatic mitochondrial dysfunction in the activities of hepatic mitochondrial respiratory chain complexes I–IV and the RCR in ducklings. However, sodium selenite could significantly ameliorate the negative effect induced by aflatoxin B1.