Immune response CC chemokines CCL2 and CCL5 are associated with pulmonary sarcoidosis

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• 作者：Vyacheslav Palchevskiy (1)
  Nastran Hashemi (1)
  Stephen S Weigt (1)
  Ying Ying Xue (1)
  Ariss Derhovanessian (1)
  Michael P Keane (2)
  Robert M Strieter (3)
  Michael C Fishbein (4)
  Jane C Deng (1)
  Joseph P Lynch III (1)
  Robert Elashoff (5)
  John A Belperio (1)
  
• 刊名：Fibrogenesis & Tissue Repair
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：4
• 期：1
• 全文大小：5281KB
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• 作者单位：Vyacheslav Palchevskiy (1)
  Nastran Hashemi (1)
  Stephen S Weigt (1)
  Ying Ying Xue (1)
  Ariss Derhovanessian (1)
  Michael P Keane (2)
  Robert M Strieter (3)
  Michael C Fishbein (4)
  Jane C Deng (1)
  Joseph P Lynch III (1)
  Robert Elashoff (5)
  John A Belperio (1)
  
  1. Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
  2. Department of Medicine, St Vincent鈥檚 University Hospital and University College Dublin, Dublin, Ireland
  3. Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
  4. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
  5. Department of Biomathematics, UCLA, Los Angeles, CA, USA
  

文摘

Background Pulmonary sarcoidosis involves an intense leukocyte infiltration of the lung with the formation of non-necrotizing granulomas. CC chemokines (chemokine (C-C motif) ligand 2 (CCL2)-CCL5) are chemoattractants of mononuclear cells and act through seven transmembrane G-coupled receptors. Previous studies have demonstrated conflicting results with regard to the associations of these chemokines with sarcoidosis. In an effort to clarify previous discrepancies, we performed the largest observational study to date of CC chemokines in bronchoalveolar lavage fluid (BALF) from patients with pulmonary sarcoidosis. Results BALF chemokine levels from 72 patients affected by pulmonary sarcoidosis were analyzed by enzyme-linked immunosorbent assay (ELISA) and compared to 8 healthy volunteers. BALF CCL3 and CCL4 levels from pulmonary sarcoidosis patients were not increased compared to controls. However, CCL2 and CCL5 levels were elevated, and subgroup analysis showed higher levels of both chemokines in all stages of pulmonary sarcoidosis. CCL2, CCL5, CC chemokine receptor type 1 (CCR1), CCR2 and CCR3 were expressed from mononuclear cells forming the lung granulomas, while CCR5 was only found on mast cells. Conclusions These data suggest that CCL2 and CCL5 are important mediators in recruiting CCR1, CCR2, and CCR3 expressing mononuclear cells as well as CCR5-expressing mast cells during all stages of pulmonary sarcoidosis.