Syntheses and properties of novel copolymers of polycaprolactone and aliphatic polycarbonate based on ketal-protected dihydroxyacetone

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• 作者：Lian-sheng Wang (1) (2)
  Si-xue Cheng (2)
  Ren-xi Zhuo (2)
  
• 关键词：Ring ; opening polymerization ; ε ; Caprolactone ; 2 ; 2 ; Ethylenedioxy ; 1 ; 3 ; propanediol carbonate ; Degradation
• 刊名：Polymer Bulletin
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：71
• 期：1
• 页码：47-56
• 全文大小：282 KB
• 作者单位：Lian-sheng Wang (1) (2)
  Si-xue Cheng (2)
  Ren-xi Zhuo (2)
  
  1. School of Chemistry and Materials Science, Hubei Engineering University, Xiaogan, 432000, Hubei, China
  2. Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, Hubei, China
  
• ISSN：1436-2449

文摘

The random copolymers of ε-caprolactone (CL) and 2,2-ethylenedioxy propane-1,3-diol carbonate (EOPDC) were synthesized in bulk at 120?°C using Sn(Oct)2 as a catalyst. The poly(EOPDC-co–CL)s obtained were characterized by FT IR, 1H NMR, 13C NMR, GPC and DSC. The copolymers were obtained with yield of 84.2-7.8?%. The number-average molecular weight of the copolymer is 2.75-.76?×?104 with a polydispersity of 1.52-.68. The properties of the copolymer including the enzymatic degradation by Pseudomonas Cepacia lipase and drug-controlled release property were also investigated. The results showed that the copolymers are degradable at physiological conditions, and their degradation rate and release of Tegafur in the copolymers increase with increasing CL content in the copolymers.