Oral MSG administration alters hepatic expression of genes for lipid and nitrogen metabolism in suckling piglets

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• 作者：Gang Chen (1) (2)
  Jun Zhang (1)
  Yuzhe Zhang (1)
  Peng Liao (1)
  Tiejun Li (1)
  Lixiang Chen (2)
  Yulong Yin (1)
  Jinquan Wang (3)
  Guoyao Wu (4) (5)
  
• 关键词：Monosodium glutamate ; Pig ; Liver ; Gene expression
• 刊名：Amino Acids
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：46
• 期：1
• 页码：245-250
• 全文大小：352 KB
• 作者单位：Gang Chen (1) (2)
  Jun Zhang (1)
  Yuzhe Zhang (1)
  Peng Liao (1)
  Tiejun Li (1)
  Lixiang Chen (2)
  Yulong Yin (1)
  Jinquan Wang (3)
  Guoyao Wu (4) (5)
  
  1. Key Laboratory of Agroecology and Processing Subtropical Region, Institute of Subtropical Agriculture, Research Center for Healthy Breeding Livestock and Poultry, Hunan Engineering and Research Center Animal and Poultry Science, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Chinese Academy of Science, Changsha, 410125, Hunan, China
  2. College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China
  3. Feed Research Institute of Chinese Academy of Agricultural Science, Beijing, 100098, China
  4. State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, 100193, China
  5. Department of Animal Science, Texas A&M University, College Station, TX, 77843, USA
  
• ISSN：1438-2199

文摘

This experiment was conducted to investigate the effects of oral administration of monosodium glutamate (MSG) on expression of genes for hepatic lipid and nitrogen metabolism in piglets. A total of 24 newborn pigs were assigned randomly into one of four treatments (n?=?6/group). The doses of oral MSG administration, given at 8:00 and 18:00 to sow-reared piglets between 0 and 21?days of age, were 0 (control), 0.06 (low dose), 0.5 (intermediate dose), and 1 (high dose) g/kg body weight/day. At the end of the 3-week treatment, serum concentrations of total protein and high-density lipoprotein cholesterol in the intermediate dose group were elevated than those in the control group (P?<?0.05). Hepatic mRNA levels for fatty acid synthase, acetyl-coA carboxylase, insulin-like growth factor-1, glutamate–oxaloacetate transaminase, and glutamate–pyruvate transaminase were higher in the middle-dose group (P?<?0.05), compared with the control group. MSG administration did not affect hepatic mRNA levels for hormone-sensitive lipase or carnitine palmitoyl transferase-1. We conclude that oral MSG administration alters hepatic expression of certain genes for lipid and nitrogen metabolism in suckling piglets.