Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders

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• 作者：Yan Zhang (1)
  Rong-Rong Mao (2)
  Zhi-Fang Chen (1)
  Meng Tian (2)
  Da-Li Tong (1)
  Zheng-Run Gao (1)
  Min Huang (1)
  Xiao Li (1)
  Xiu Xu (5)
  Wen-Hao Zhou (4)
  Cheng-Yu Li (1)
  Jiang Wang (3)
  Lin Xu (2)
  Zilong Qiu (1)
  
• 关键词：Deep ; brain magnetic stimulation ; Adult hippocampal neurogenesis ; Long ; term potentiation ; Depression ; MeCP2 ; Rett syndrome
• 刊名：Molecular Brain
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：7
• 期：1
• 全文大小：1,179 KB
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• 作者单位：Yan Zhang (1)
  Rong-Rong Mao (2)
  Zhi-Fang Chen (1)
  Meng Tian (2)
  Da-Li Tong (1)
  Zheng-Run Gao (1)
  Min Huang (1)
  Xiao Li (1)
  Xiu Xu (5)
  Wen-Hao Zhou (4)
  Cheng-Yu Li (1)
  Jiang Wang (3)
  Lin Xu (2)
  Zilong Qiu (1)
  
  1. Institute of Neuroscience, Chinese Academy of Sciences, Shanghai Institutes for Biological Sciences, Shanghai, China
  2. Key Laboratory of Animal Models and Human Disease Mechanisms, Laboratory of Learning and Memory, Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming, Yunnan, China
  5. Department of Child Healthcare, Children鈥檚 Hospital of Fudan University, Shanghai, China
  4. Departments of Neonatology, Children鈥檚 Hospital of Fudan University, Shanghai, China
  3. School of Electrical and Automation Engineering, Tianjin University, Tianjin, China
  
• ISSN：1756-6606

文摘

Background Repetitive Transcranial Magnetic Stimulation (rTMS)/ Deep-brain Magnetic Stimulation (DMS) is an effective therapy for various neuropsychiatric disorders including major depression disorder. The molecular and cellular mechanisms underlying the impacts of rTMS/DMS on the brain are not yet fully understood. Results Here we studied the effects of deep-brain magnetic stimulation to brain on the molecular and cellular level. We examined the adult hippocampal neurogenesis and hippocampal synaptic plasticity of rodent under stress conditions with deep-brain magnetic stimulation treatment. We found that DMS promotes adult hippocampal neurogenesis significantly and facilitates the development of adult new-born neurons. Remarkably, DMS exerts anti-depression effects in the learned helplessness mouse model and rescues hippocampal long-term plasticity impaired by restraint stress in rats. Moreover, DMS alleviates the stress response in a mouse model for Rett syndrome and prolongs the life span of these animals dramatically. Conclusions Deep-brain magnetic stimulation greatly facilitates adult hippocampal neurogenesis and maturation, also alleviates depression and stress-related responses in animal models.