MTHFR C677T polymorphism contributes to the risk for gastric cancer

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• 作者：Shushan Yan (1)
  Donghua Xu (2)
  Pingping Wang (3)
  Ping Wang (4)
  Chengcheng Liu (5)
  Changjiang Hua (1)
  Tao Jiang (1)
  Bin Zhang (1)
  Zengcai Li (1)
  Lei Lu (1)
  Xianzhong Liu (1)
  Bingji Wang (1)
  Donghua Zhang (1)
  Rongsheng Zhang (1)
  Shaoheng He (5) (6)
  Beicheng Sun (4)
  Xuan Wang (1)
  
• 关键词：Gastric cancer ; MTHFR C677T ; Polymorphisms ; Meta ; analysis
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：March 2014
• 年：2014
• 卷：35
• 期：3
• 页码：2123-2132
• 全文大小：313 KB
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• 作者单位：Shushan Yan (1)
  Donghua Xu (2)
  Pingping Wang (3)
  Ping Wang (4)
  Chengcheng Liu (5)
  Changjiang Hua (1)
  Tao Jiang (1)
  Bin Zhang (1)
  Zengcai Li (1)
  Lei Lu (1)
  Xianzhong Liu (1)
  Bingji Wang (1)
  Donghua Zhang (1)
  Rongsheng Zhang (1)
  Shaoheng He (5) (6)
  Beicheng Sun (4)
  Xuan Wang (1)
  
  1. Department of Surgical Oncology, The Eighty-First Hospital of People’s Liberation Army, Nanjing, 210002, Jiangsu Province, China
  2. Department of Rheumatism, The First Affiliated Hospital, Nanjing Medical University, Nanjing, 210029, China
  3. Department of Obstetrics and Gynecology, Weifang Maternal and Child Health Hospital, Weifang, 261000, China
  4. Liver Transplantation Center of the First Affiliated Hospital, Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China
  5. Clinical Research Centre, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China
  6. Allergy and Clinical Immunology Research Center, The First Affiliated Hospital of Liaoning Medical College, Jinzhou, 121000, China
  
• ISSN：1423-0380

文摘

Methylenetetrahydrofolate reductase (MTHFR) has been demonstrated to be involved in carcinogenesis. Increasing individual studies have investigated the role of MTHFR C677T polymorphism in gastric cancer pathogenesis, but with inconsistent findings. The aim of this study was to clarify the potential association of the MTHFR C677T polymorphism with gastric cancer risk by pooling all available data from published case–control studies. We searched the PubMed, Embase, Web of Science, and Wanfang databases for all relevant publications to date. The pooled odds ratio (OR) with corresponding 95?% confidence interval (95?% CI) was calculated. Stratified analysis and sensitivity analysis were also carried out to estimate the strength of this association. A total of 25 case–control studies with 6,572 cases and 9,584 controls were retrieved. Overall, the ORs under five contrast models indicated that the MTHFR C677T variant was positively associated with gastric cancer risk (ORT vs. C--.21, 95?% CI 1.10-.34, P OR-lt;-.001; ORTT vs. CC--.47, 95?% CI 1.22-.76, P OR-lt;-.001; ORTC vs. CC--.20, 95?% CI 1.03-.40, P OR--.022; ORTT-?TC?vs.?CC--.27, 95?% CI 1.10-.47, P OR--.001; ORTT?vs.?CC-?TC--.29, 95?% CI 1.15-.46, P OR-lt;-.001). Stratified analyses according to ethnicity and source of controls further confirmed the significant correlations. The current meta-analysis provides strong evidence that the MTHFR C677T polymorphism may be a risk factor for gastric cancer among Asians and Caucasians.