Serum SPARC and Matrix Metalloproteinase-2 and Metalloproteinase-9 Concentrations after Bariatric Surgery in Obese Adults

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• 作者：Yeon Ji Lee (1)
  Yoon-Seok Heo (2)
  Hye Soon Park (3)
  Seoung Hee Lee (3)
  Seul Ki Lee (4)
  Yeon Jin Jang (4)
  
• 关键词：Serum SPARC concentration ; MMP ; 2 ; MMP ; 9 ; Bariatric surgery
• 刊名：Obesity Surgery
• 出版年：2014
• 出版时间：April 2014
• 年：2014
• 卷：24
• 期：4
• 页码：604-610
• 全文大小：222 KB
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• 作者单位：Yeon Ji Lee (1)
  Yoon-Seok Heo (2)
  Hye Soon Park (3)
  Seoung Hee Lee (3)
  Seul Ki Lee (4)
  Yeon Jin Jang (4)
  
  1. Department of Family Medicine, College of Medicine, Inha University, 7-206, Sinheung-dong 3-Ga, Jung-gu, Incheon, 400-711, South Korea
  2. Department of General Surgery, College of Medicine, Inha University, 7-206, Sinheung-dong 3-Ga, Jung-gu, Incheon, 400-711, South Korea
  3. Department of Family Medicine, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-gu, Seoul, 138-736, South Korea
  4. Department of Physiology, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-gu, Seoul, 138-736, South Korea
  
• ISSN：1708-0428

文摘

Background Remodeling of the extracellular matrix (ECM) of adipose tissue is regarded as part of the pathophysiology of obesity. Secreted protein acidic and rich in cysteine (SPARC) was the first ECM protein described in adipose tissue. Matrix metalloproteinases (MMPs) also play a role in ECM remodeling, and MMP-2 and MMP-9 may be associated with abnormal ECM metabolism. Here, we investigated changes in serum SPARC, MMP-2, and MMP-9 concentrations after bariatric surgery in obese adults. Methods We recruited 34 obese patients who were scheduled to undergo bariatric surgery for weight loss. We analyzed changes in serum SPARC, MMP-2, and MMP-9 concentrations before and 9?months after bariatric surgery and any associations between changes in SPARC, MMP-2, and MMP-9 concentrations and obesity-related parameters. Results Serum leptin levels significantly decreased, and the serum adiponectin level significantly increased after bariatric surgery. The serum SPARC concentration decreased significantly from 165.0?±-8.2 to 68.7?±-.7?ng/mL (p-lt;-.001), and the MMP-2 concentration also decreased significantly from 262.2?±-5.2 to 235.9?±-0.5?ng/mL (p-lt;-.001). Changes in the serum SPARC concentration were significantly correlated with HOMA-IR changes, and changes in the serum MMP-9 concentration were found to inversely correlate with serum adiponectin changes. Conclusion These findings show that significant decreases in serum SPARC and MMP-2 concentrations occur after bariatric surgery. Our results thus suggest that weight loss via bariatric surgery could alter the ECM environment, and that these changes are related to certain metabolic changes.