3D iteratively reconstructed spatial resolution map and sensitivity characterization of a dedicated cardiac SPECT camera

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• 作者：John A. Kennedy PhD (1)
  Ora Israel MD (1) (2)
  Alex Frenkel PhD (1)
  
• 关键词：Myocardial perfusion imaging ; SPECT ; instrumentation ; SPECT ; ultrafast cardiac gamma camera ; cadmium ; zinc ; telluride
• 刊名：Journal of Nuclear Cardiology
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：21
• 期：3
• 页码：443-452
• 全文大小：
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• 作者单位：John A. Kennedy PhD (1)
  Ora Israel MD (1) (2)
  Alex Frenkel PhD (1)
  
  1. Department of Nuclear Medicine, Rambam Health Care Campus, P.O. Box 9602, 31096, Haifa, Israel
  2. B. and R. Rappaport School of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
  
• ISSN：1532-6551

文摘

Background A solid-state cadmium zinc telluride (CZT) SPECT device provides ultrafast myocardial perfusion imaging (MPI) with a spherical field-of-view (FOV). This study aims at determining the spatial resolution and sensitivity throughout this FOV as a guide for patient positioning. Methods and Results For this CZT camera (Discovery 570c, GE Healthcare), the iteratively reconstructed spatial resolution along 3 Cartesian axes was compared (average resolution 6.9?±?1.0?mm full-width at half-maximum) using a 2 dimensional array of point sources in air which was aligned with a transverse plane shifted throughout the FOV. Sensitivity was plotted in the central transverse slice and axially in locations comparable to the placement of the heart in 266 rest/stress cardiac studies (M 78, age 63?±?13?years). The average sensitivity was 0.46?±?0.19?kc/s/MBq with a transverse gradient of 0.039?±?0.001?kc/s/MBq/cm (8.9% of the sensitivity per cm). Reconstructed relative activity was uniform (uniformity <9%) and count rate was linear (R?=?0.999) over 3 orders of magnitude. Conclusions The CZT SPECT camera offers good resolution, sensitivity, and uniformity, and provides linearity in count rate. A gradient of >8%/cm in sensitivity justifies the crucial role of patient positioning with the heart closest to the detector.