Acaricidal activity of usnic acid and sodium usnic acid against Psoroptes cuniculi in vitro

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• 作者：Xiaofei Shang (1)
  Xiaolou Miao (1)
  Huiping Lv (2)
  Dongsheng Wang (1)
  Jiqin Zhang (1)
  Hua He (3)
  Zhiqiang Yang (1)
  Hu Pan (1)
  
• 关键词：Acaricidal activity ; Usnic acid ; Sodium usnic acid ; Psoroptes cuniculi
• 刊名：Parasitology Research
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：113
• 期：6
• 页码：2387-2390
• 全文大小：
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• 作者单位：Xiaofei Shang (1)
  Xiaolou Miao (1)
  Huiping Lv (2)
  Dongsheng Wang (1)
  Jiqin Zhang (1)
  Hua He (3)
  Zhiqiang Yang (1)
  Hu Pan (1)
  
  1. Key Laboratory of New Animal Drug Project, Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Science, Lanzhou, 730050, People’s Republic of China
  2. Department of Emergency, The People’s Hospital of Jingchuan County, Jingchuan, 744300, People’s Republic of China
  3. Department of Pharmacy, Wenzhou Medical College, Wenzhou, 325035, People’s Republic of China
  
• ISSN：1432-1955

文摘

Usnic acid, a major active compound in lichens, was first isolated in 1884. Since then, usnic acid and its sodium salt (sodium usnic acid) have been used in medicine, perfumery, cosmetics, and other industries due to its extensive biological activities. However, its acaricidal activity has not been studied. In this paper, we investigated the acaricidal activity of usnic acid and sodium usnic acid against Psoroptes cuniculi in vitro. After evaluating the acaricidal activity and toxicity of usnic acid and sodium usnic acid in vitro, the results showed that at doses of 250, 125, and 62.5?mg/ml, usnic acid and sodium usnic acid can kill mites with 91.67, 85.00, and 55.00?% and 100, 100, and 60.00?% mortality after treatment 24?h. The LT50 values were 4.208, 8.249, and 16.950?h and 3.712, 7.339, and 15.773?h for usnic acid and sodium usnic acid, respectively. Sodium usnic acid has a higher acaricidal activity than usnic acid, which may be related to the difference in their structures.