The effect of childhood trauma on spatial cognition in adults: a possible role of sex

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• 作者：Supriya Syal (1) (4) (5)
  Jonathan Ipser (1)
  Nicole Phillips (1)
  Kevin G. F. Thomas (2)
  Jack van der Honk (1) (3)
  Dan J. Stein (1)
  
• 关键词：Childhood adversity ; Visuo ; spatial ability ; Cantab ; Sex ; Stress
• 刊名：Metabolic Brain Disease
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：29
• 期：2
• 页码：301-310
• 全文大小：
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• 作者单位：Supriya Syal (1) (4) (5)
  Jonathan Ipser (1)
  Nicole Phillips (1)
  Kevin G. F. Thomas (2)
  Jack van der Honk (1) (3)
  Dan J. Stein (1)
  
  1. Department of Psychiatry and Mental Health, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa
  4. 92, UCT Department of Psychiatry and Mental Health, Groote Schuur Hospital (J-2), Anzio Rd, Observatory, 7925, Cape Town, South Africa
  5. Department of Psychology, University of Toronto, Toronto, Canada
  2. Department of Psychology, University of Cape Town, Cape Town, South Africa
  3. Department of Psychology, Utrecht University, Utrecht, Netherlands
  
• ISSN：1573-7365

文摘

Although animal evidence indicates that early life trauma results in pervasive hippocampal deficits underlying spatial and cognitive impairment, visuo-spatial data from adult humans with early childhood adversity are lacking. We administered 4 tests of visuo-spatial ability from the Cambridge Neuorpsychological Test Automated Battery (CANTAB) to adults with a history of childhood trauma (measured by the Childhood Trauma Questionnaire) and a matched sample of healthy controls (trauma/control--7/28). We observed a significant effect of trauma history on spatial/pattern learning. These effects could not be accounted for by adverse adult experiences, and were sex-specific, with prior adversity improving performance in men but worsening performance in women, relative to controls. Limitations include the small sample size and reliance of our study design on a retrospective, self report measure. Our results suggest that early adversity can lead to specific and pervasive deficits in adult cognitive function.