Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory

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• 作者：Stéphanie M. van den Berg (1) (51)
  Marleen H. M. de Moor (2)
  Matt McGue (3) (4)
  Erik Pettersson (5)
  Antonio Terracciano (6) (7)
  Karin J. H. Verweij (8) (9)
  Najaf Amin (10)
  Jaime Derringer (11)
  T?nu Esko (12)
  Gerard van Grootheest (13)
  Narelle K. Hansell (8)
  Jennifer Huffman (14)
  Bettina Konte (15)
  Jari Lahti (16) (17)
  Michelle Luciano (18) (19)
  Lindsay K. Matteson (3)
  Alexander Viktorin (5)
  Jasper Wouda (2)
  Arpana Agrawal (20)
  Jüri Allik (21) (22)
  Laura Bierut (20)
  Ulla Broms (23) (24)
  Harry Campbell (25)
  George Davey Smith (26)
  Johan G. Eriksson (17) (24) (27) (28) (29)
  Luigi Ferrucci (6)
  Barbera Franke (30) (31) (32)
  Jean-Paul Fox (1)
  Eco J. C. de Geus (2)
  Ina Giegling (15)
  Alan J. Gow (33)
  Richard Grucza (20)
  Annette M. Hartmann (15)
  Andrew C. Heath (20)
  Kauko Heikkil? (23)
  William G. Iacono (3)
  Joost Janzing (31)
  Markus Jokela (16) (34)
  Lambertus Kiemeney (35) (36)
  Terho Lehtim?ki (34)
  Pamela A. F. Madden (20)
  Patrik K. E. Magnusson (5)
  Kate Northstone (26)
  Teresa Nutile (37)
  Klaasjan G. Ouwens (2)
  Aarno Palotie (38) (39)
  Alison Pattie (18) (19)
  Anu-Katriina Pesonen (16)
  Ozren Polasek (40)
  Lea Pulkkinen (41)
  Laura Pulkki-R?back (16)
  Olli T. Raitakari (42) (43)
  Anu Realo (21)
  Richard J. Rose (44)
  Daniela Ruggiero (37)
  Ilkka Sepp?l? (34)
  Wendy S. Slutske (45)
  David C. Smyth (8)
  Rossella Sorice (37)
  John M. Starr (19)
  Angelina R. Sutin (6) (7)
  Toshiko Tanaka (6)
  Josine Verhagen (46)
  Sita Vermeulen (32) (35)
  Eero Vuoksimaa (23) (47)
  Elisabeth Widen (39)
  Gonneke Willemsen (2)
  Margaret J. Wright (8)
  Lina Zgaga (25) (48)
  Dan Rujescu (15)
  Andres Metspalu (12) (22)
  James F. Wilson (25)
  Marina Ciullo (37)
  Caroline Hayward (14)
  Igor Rudan (25)
  Ian J. Deary (18) (19)
  Katri R?ikk?nen (16) (17) (24)
  Alejandro Arias Vasquez (30) (31) (32) (49)
  Paul T. Costa (50)
  Liisa Keltikangas-J?rvinen (16)
  Cornelia M. van Duijn (10)
  Brenda W. J. H. Penninx (13)
  Robert F. Krueger (3)
  David M. Evans (26)
  Jaakko Kaprio (23) (24) (39)
  Nancy L. Pedersen (5)
  Nicholas G. Martin (8)
  Dorret I. Boomsma (2)
  
• 关键词：Personality ; Item ; Response Theory ; Measurement ; Genome ; wide association studies ; Consortium ; Meta ; analysis
• 刊名：Behavior Genetics
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：44
• 期：4
• 页码：295-313
• 全文大小：
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• 作者单位：Stéphanie M. van den Berg (1) (51)
  Marleen H. M. de Moor (2)
  Matt McGue (3) (4)
  Erik Pettersson (5)
  Antonio Terracciano (6) (7)
  Karin J. H. Verweij (8) (9)
  Najaf Amin (10)
  Jaime Derringer (11)
  T?nu Esko (12)
  Gerard van Grootheest (13)
  Narelle K. Hansell (8)
  Jennifer Huffman (14)
  Bettina Konte (15)
  Jari Lahti (16) (17)
  Michelle Luciano (18) (19)
  Lindsay K. Matteson (3)
  Alexander Viktorin (5)
  Jasper Wouda (2)
  Arpana Agrawal (20)
  Jüri Allik (21) (22)
  Laura Bierut (20)
  Ulla Broms (23) (24)
  Harry Campbell (25)
  George Davey Smith (26)
  Johan G. Eriksson (17) (24) (27) (28) (29)
  Luigi Ferrucci (6)
  Barbera Franke (30) (31) (32)
  Jean-Paul Fox (1)
  Eco J. C. de Geus (2)
  Ina Giegling (15)
  Alan J. Gow (33)
  Richard Grucza (20)
  Annette M. Hartmann (15)
  Andrew C. Heath (20)
  Kauko Heikkil? (23)
  William G. Iacono (3)
  Joost Janzing (31)
  Markus Jokela (16) (34)
  Lambertus Kiemeney (35) (36)
  Terho Lehtim?ki (34)
  Pamela A. F. Madden (20)
  Patrik K. E. Magnusson (5)
  Kate Northstone (26)
  Teresa Nutile (37)
  Klaasjan G. Ouwens (2)
  Aarno Palotie (38) (39)
  Alison Pattie (18) (19)
  Anu-Katriina Pesonen (16)
  Ozren Polasek (40)
  Lea Pulkkinen (41)
  Laura Pulkki-R?back (16)
  Olli T. Raitakari (42) (43)
  Anu Realo (21)
  Richard J. Rose (44)
  Daniela Ruggiero (37)
  Ilkka Sepp?l? (34)
  Wendy S. Slutske (45)
  David C. Smyth (8)
  Rossella Sorice (37)
  John M. Starr (19)
  Angelina R. Sutin (6) (7)
  Toshiko Tanaka (6)
  Josine Verhagen (46)
  Sita Vermeulen (32) (35)
  Eero Vuoksimaa (23) (47)
  Elisabeth Widen (39)
  Gonneke Willemsen (2)
  Margaret J. Wright (8)
  Lina Zgaga (25) (48)
  Dan Rujescu (15)
  Andres Metspalu (12) (22)
  James F. Wilson (25)
  Marina Ciullo (37)
  Caroline Hayward (14)
  Igor Rudan (25)
  Ian J. Deary (18) (19)
  Katri R?ikk?nen (16) (17) (24)
  Alejandro Arias Vasquez (30) (31) (32) (49)
  Paul T. Costa (50)
  Liisa Keltikangas-J?rvinen (16)
  Cornelia M. van Duijn (10)
  Brenda W. J. H. Penninx (13)
  Robert F. Krueger (3)
  David M. Evans (26)
  Jaakko Kaprio (23) (24) (39)
  Nancy L. Pedersen (5)
  Nicholas G. Martin (8)
  Dorret I. Boomsma (2)
  
  1. Department of Research Methodology, Measurement and Data-Analysis, University of Twente, Enschede, The Netherlands
  51. Department of Behavioural Sciences, OMD, University of Twente, PO Box 217, 7500 AE, Enschede, The Netherlands
  2. Department of Biological Psychology, VU University, Amsterdam, The Netherlands
  3. Department of Psychology, University of Minnesota, Elliott Hall, Minneapolis, MN, USA
  4. Institute of Public Health, University of Southern Denmark, Odense, Denmark
  5. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  6. National Institute on Aging, NIH, Baltimore, MD, USA
  7. College of Medicine, Florida State University, Tallahassee, FL, USA
  8. QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
  9. Department of Developmental Psychology and EMGO Institute for Health and Care Research, VU University Amsterdam, Amsterdam, The Netherlands
  10. Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
  11. Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, IL, USA
  12. Estonian Genome Center, University of Tartu, Tartu, Estonia
  13. Department of Psychiatry, EMGO+ Institute, Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
  14. MRC Human Genetics, MRC IGMM, Western General Hospital, University of Edinburgh, Edinburgh, Scotland, UK
  15. Department of Psychiatry, University of Halle, Halle, Germany
  16. Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland
  17. Folkh?lsan Research Center, Helsinki, Finland
  18. Department of Psychology, University of Edinburgh, Edinburgh, UK
  19. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
  20. Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA
  21. Department of Psychology, University of Tartu, Tartu, Estonia
  22. Estonian Academy of Sciences, Tallinn, Estonia
  23. Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland
  24. National Institute for Health and Welfare (THL), Helsinki, Finland
  25. Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, UK
  26. MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK
  27. Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland
  28. Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland
  29. Vasa Central Hospital, Vaasa, Finland
  30. Donders Institute for Cognitive Neuroscience, Radboud University Nijmegen, Nijmegen, The Netherlands
  31. Department of Psychiatry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
  32. Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
  33. Department of Psychology, School of Life Sciences, Heriot-Watt University, Edinburgh, UK
  34. Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland
  35. Department of Health Evidence, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
  36. Department of Urology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
  37. Institute of Genetics and Biophysics “A. Buzzati-Traverso--CNR, Naples, Italy
  38. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
  39. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
  40. Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia
  41. Department of Psychology, University of Jyv?skyl?, Jyv?skyl?, Finland
  42. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
  43. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
  44. Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN, USA
  45. Department of Psychological Sciences and Missouri Alcoholism Research Center, University of Missouri, Columbia, MO, USA
  46. Department of Psychological Methods, University of Amsterdam, Amsterdam, The Netherlands
  47. Department of Psychiatry, University of California, La Jolla, CA, USA
  48. Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland
  49. Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
  50. Behavioral Medicine Research Center, Duke University School of Medicine, Durham, NC, USA
  
• ISSN：1573-3297

文摘

Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant personality traits, Neuroticism and Extraversion, how Item-Response Theory (IRT) can be applied to map item data from different inventories to the same underlying constructs. Personality item data were analyzed in >160,000 individuals from 23 cohorts across Europe, USA and Australia in which Neuroticism and Extraversion were assessed by nine different personality inventories. Results showed that harmonization was very successful for most personality inventories and moderately successful for some. Neuroticism and Extraversion inventories were largely measurement invariant across cohorts, in particular when comparing cohorts from countries where the same language is spoken. The IRT-based scores for Neuroticism and Extraversion were heritable (48 and 49?%, respectively, based on a meta-analysis of six twin cohorts, total N?=?29,496 and 29,501 twin pairs, respectively) with a significant part of the heritability due to non-additive genetic factors. For Extraversion, these genetic factors qualitatively differ across sexes. We showed that our IRT method can lead to a large increase in sample size and therefore statistical power. The IRT approach may be applied to any mega- or meta-analytic study in which item-based behavioral measures need to be harmonized.