Regenerable antimicrobial N-halamine/silica hybrid nanoparticles

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• 作者：Lianhong Zhao (1)
  Xiufang Yan (1)
  Zhiqiang Jie (1)
  Hong Yang (1)
  Shiping Yang (1)
  Jie Liang (1)
  
• 关键词：Regenerable ; Silica ; Synthesis ; N ; halamine ; Antimicrobial
• 刊名：Journal of Nanoparticle Research
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：16
• 期：7
• 全文大小：
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• 作者单位：Lianhong Zhao (1)
  Xiufang Yan (1)
  Zhiqiang Jie (1)
  Hong Yang (1)
  Shiping Yang (1)
  Jie Liang (1)
  
  1. The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai, 200234, People’s Republic of China
  
• ISSN：1572-896X

文摘

Regenerable antimicrobial N-halamine/silica hybrid nanoparticles (NPs) containing chlorinated 5,5-dimethylhydantoinyl (Cl-DMH) groups, Cl-DMH/SiO2 hybrid NPs, have been prepared by a co-condensation reaction between N-(3-triethoxysilylpropyl)-5,5-dimethylhydantoin (TS-DMH) and tetraethoxysilane (TEOS) and then a chlorination reaction in NaClO solution. The as-synthesized Cl-DMH/SiO2 NPs were characterized by transmission electron microscopy, Scanning electron microscopy, X-ray photoelectron spectra, Specific surface area, Differential scanning calorimetry, and Fourier transform infrared. Experimental results showed that the size of the as-synthesized Cl-DMH/SiO2 NPs could be well adjusted by changing the mass ratio of TS-DMH/TEOS and the volume ratio of 28?% NH4OH/H2O. Antimicrobial tests showed that the as-prepared Cl-DMH/SiO2 hybrid NPs had excellent antimicrobial activities against both Escherichia coli and Staphylococcus aureus. The minimum inhibitory concentration and minimum bactericidal concentration values of the as-prepared Cl-DMH/SiO2 hybrid NPs are 15 and 20?μg/mL for S. aureus, 25 and 30?μg/mL for E. coli, respectively. Paper disk diffusion assay showed that smaller-sized Cl-DMH/SiO2 hybrid NPs have bigger inhibition zone diameters, indicating stronger antimicrobial efficacies. Also, the storage stability and regenerability of Cl-DMH/SiO2 hybrid NPs were investigated.