The synthesis of a new cardiac sympathetic nerve imaging agent N-[11C]CH3-dopamine and biodistribution study

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• 作者：Yulin He (1)
  Weina Zhou (1)
  Xiangcheng Wang (1)
  Baoliang Bao (1)
  Guojian Zhang (1)
  Cheng Wang (1)
  Chunmei Wang (1)
  Xuemei Wang (1)
  Wei Fang (2)
  
• 关键词：N ; [11C]CH3 ; dopamine ; Myocardial innervation ; Sympathetic imaging
• 刊名：Journal of Radioanalytical and Nuclear Chemistry
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：301
• 期：2
• 页码：469-474
• 全文大小：616 KB
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• 作者单位：Yulin He (1)
  Weina Zhou (1)
  Xiangcheng Wang (1)
  Baoliang Bao (1)
  Guojian Zhang (1)
  Cheng Wang (1)
  Chunmei Wang (1)
  Xuemei Wang (1)
  Wei Fang (2)
  
  1. Department of Nuclear Medicine, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, China
  2. Department of Nuclear Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100037, China
  
• ISSN：1588-2780

文摘

In this study, we synthesized and characterized N-[11C]methyl-dopamine ([11C]MDA) for cardiac sympathetic nerve imaging. [11C]MDA was synthesized by direct N-methylation of dopamine with [11C]methyl iodide and purified by semi-preparation reverse high pressure liquid chromatography (HPLC). The total synthesis time was 45?min including HPLC purification. The radiochemical yields of [11C]MDA was 20?±?3?%, without decay correction. The radiochemical purity was >98?% and the specific activity was about 50?GBq/mmol. The biological properties of [11C]MDA were evaluated by biodistribution study in normal mice. PET imaging was performed in healthy Chinese mini-swines. Biodistribution study showed that [11C]MDA had high myocardium uptake. PET/CT imaging showed [11C]MDA had clear and symmetrical myocardium uptake, which was blocked obviously by injecting imipramine hydrochloride. [11C]MDA would be a promising candidate of radiotracer for cardiac sympathetic nervous system imaging.