Mechanisms Underlying the Effect of Acupuncture on Cognitive Improvement: A Systematic Review of Animal Studies

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• 作者：Mason Chin Pang Leung (1)
  Ka Keung Yip (2)
  Yuen Shan Ho (3)
  Flora Ka Wai Siu (4)
  Wai Chin Li (5)
  Belinda Garner (6)
  
• 关键词：Acupuncture ; Cognitive ; Dementia ; Alzheimer鈥檚 disease ; Parkinson鈥檚 disease
• 刊名：Journal of Neuroimmune Pharmacology
• 出版年：2014
• 出版时间：September 2014
• 年：2014
• 卷：9
• 期：4
• 页码：492-507
• 全文大小：1,067 KB
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• 作者单位：Mason Chin Pang Leung (1)
  Ka Keung Yip (2)
  Yuen Shan Ho (3)
  Flora Ka Wai Siu (4)
  Wai Chin Li (5)
  Belinda Garner (6)
  
  1. Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, Special Administrative Region, China
  2. Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, Special Administrative Region, China
  3. State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, People鈥檚 Republic of China
  4. Centralized Animal Facility, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, Special Administrative Region, China
  5. Centre for Education in Environmental Sustainability and Department of Science and Environmental Studies, The Hong Kong Institute of Education, Tai Po Hong Kong, Special Administrative Region, China
  6. Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, Special Administrative Region, China
  
• ISSN：1557-1904

文摘

Acupuncture has been reported to be beneficial in treating cognitive impairment in various pathological conditions. This review describes the effort to understand the signaling pathways that underlie the acupunctural therapeutic effect on cognitive function. We searched the literature in 12 electronic databases from their inception to November 2013, with full text available and language limited to English. Twenty-three studies were identified under the selection criteria. All recruited animal studies demonstrate a significant positive effect of acupuncture on cognitive impairment. Findings suggest acupuncture may improve cognitive function through modulation of signaling pathways involved in neuronal survival and function, specifically, through promoting cholinergic neural transmission, facilitating dopaminergic synaptic transmission, enhancing neurotrophin signaling, suppressing oxidative stress, attenuating apoptosis, regulating glycometabolic enzymes and reducing microglial activation. However, the quality of reviewed studies has room for improvement. Further high-quality animal studies with randomization, blinding and estimation of sample size are needed to strengthen the recognition of group differences.